(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
CAS: 26159-34-2
Molecular Formula: C14H13O3.Na
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt - Names and Identifiers
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt - Physico-chemical Properties
| Molecular Formula | C14H13O3.Na |
| Molar Mass | 252.24 |
| Melting Point | 250-251°C |
| Boling Point | 403.9°C at 760 mmHg |
| Specific Rotation(α) | D -11° (in methanol) |
| Flash Point | 154.5°C |
| Water Solubility | Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water. |
| Solubility | Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent). |
| Vapor Presure | 3.01E-07mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Naproxen acts on intact cells and inhibits COX-1 and COX-2 with an IC50 of 2.2 μg/mL and 1.3 μg/mL, respectively. In Vitro, Naproxen acts on rats and humans to reduce the production of PGE 2 and TXB 2 induced by LPS, and when PGE 2 is inhibited, the IC50 is 30.7 μm and 79.5 μm, respectively, when TXB 2 was inhibited, the IC50 was 72.4 μm and 48.3 μm, respectively. Naproxen inhibited human platelet TXB 2 Production and LPS-induced human monocyte TXB 2 production with IC50 of 5.7 and 6.4, respectively, and also slightly selectively inhibited constitutive and inducible COX-2, the ratio of the IC50 value acting on COX-1 to the IC50 value acting on COX-2 is 6.3. Only high concentration of Naproxen on HCA-7 colon cancer cells for 48 hours, can significantly induce apoptosis, IC50 is 1.45 mM. |
| In vivo study | In Vivo, treatment of rats by Naproxen reduced the production of PGE 2 and TXB 2 induced by LPS with IC50 of 12.8 μm and 5.9 μm, respectively, indicating that Naproxen is a non-selective COX inhibitor. Naproxen acts on the analgesia rat model of Carrageenan-induced arthritis, IC50 is 27 μm, and on yeast-induced fever rats, IC50 is 40 μm, when PGE 2 and TXB 2 are inhibited, the IC50 was 13 μm and 5 μm, respectively. |
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R61 - May cause harm to the unborn child |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | QJ1047000 |
| HS Code | 2918992090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
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